Dr. M. Karthikeyan

Assistant Professor, Department of Bioinformatics

Research Publication                                                                                                                                                                                           Citations

Accepted Articles/Epub ahead of print
70. Lakshmanan Loganathan, Karthikeyan Muthusamy*, John Marshal Jayaraj, Afrinrilwana Kajamaideen, Josephine Julia Balthasar. In silico insights on Tankyrase protein: a potential target for colorectal cancer. Journal of Biomolecular structure and dynamics. (Accepted). (IF: 3.107).
69. Lakshmanan Loganathan and Karthikeyan Muthusamy*. Investigation of drug interaction potentials and binding modes on direct renin inhibitors. A computational modeling study. Letters in Drug Design and Discovery, August 2018, 15. DOI: 10.2174/1570180815666180827113622. (IF: 0.961).
68. Selvaraman Nagamani, Chandrasekhar Kesavan and Karthikeyan Muthusamy*. Atom-based and Pharmacophore-based 3D – QSAR Studies on Vitamin D Receptor (VDR). Combinatorial Chemistry & High Throughput Screening. Doi: 10.2174/1386207321666180607101720. PMID: 29874993. (IF: 1.205)
67. Jayaraj John Marshal, Gopinath Krishnasamy, Jung-Kul Lee and Karthikeyan Muthusamy*. In silico identification and screening of CYP24A1 inhibitors: 3D QSAR pharmacophore mapping and molecular dynamics analysis. Journal of Biomolecular Structure and Dynamics. May 2018. Doi: 10.1080/07391102.2018.1464958, PMID: 29658431. (IF: 3.107)
66. Jayaseelan Vijayashree Priyadharsini,Muthusamy Karthikeyan, Venkatraman Shridevi, Arumugam Paramasivam, Gopalswamy Jayaraman, Thiagarajan Santhiya Sathiyavedu. Association of SH2B3 (rs3184504) polymorphism in essential hypertensive patients in south Indian population. International Journal of Life Sciences. Volume 6, No.1, 2018.
65. Anusha Chidambaram, Ramesh Kumar, Rajasekaran, john Marshal Jayaraj, Karthikeyan Muthusamy, Ravikumar. Design, synthesis and characterization of α, β-unsaturated carboxylic acid and its urea based derivatives that explores novel epigenetic modulators in human non-small lung cancer A549 cell line. Journal of Cellular Physiology. Nov 2017. (IF: 4.08). Jan 2018 233(7):5293-5309. Doi: 10.1002/jcp.26333. PMID: 29215703. (IF: 4.08)
64. Karthikeyan Muthusamy*, Nagamani Selvaraman, Kesavan Chandrasekhar. Vitamin D Receptor (VDR) non-synonymous Single Nucleotide Polymorphisms (nsSNPs) affect the Calcitriol Drug Response - a theoretical Insight. Journal of Molecular Graphics and Modelling. 2018 May;81:14-24. DOI: 10.1016/j.jmgm.2018.02.004. PMID: 29476931. (IF: 1.74)
63. Santhiya Sathiyavedu Thiagarajan*, Vijayashree Priyadharsini Jayaseelan, Jayaraman Gopalswamy, Karthikeyan Muthusamy, Shridevi Venkatraman and Paramasivam Arumugam. Gender-specific Association of ATP2B1 (Rs2681472) Gene Polymorphism with Essential Hypertension in South Indian Population. International Journal of Human Genetics (IJHG) Feb 2018 Volume 17, 169-176. DOI: 10.1080/09723757.2017.1421431. (IF: 0.146)
62. Gopinath Krishnaswamy, Nagarajan Subbiah, Karthikeyan Muthusamy*. Isolation of natural compounds from Syzygium densiflorum fruits and exploring its chemical property, therapeutic role in diabetic management. The Natural Products Journal. (Accepted).
61. Dhamotharan Pattarayan, Ayyanar Sivanantham, Venkateshwaran Krishnaswami, Lakshmanan Loganathan, Rajaguru Palanichamy, Subramanian Natesan, Karthikeyan Muthusamy and Rajasekaran Subbiah. Tannic acid Attenuates TGF-β1-induced Epithelial-to-mesenchymal Transition by Effectively Intervening TGF-β Signaling in Lung Epithelial Cells. Journal of Cellular Physiology. 2017;1–13. (IF: 4.08), DOI: 10.1002/jcp.26127.
60. Karthikeyan Muthusamy*, Sathishkumar Chinnasamy, Pappathi Palanisamy, Gopinath Krishnasamy. Clematis gouriana roxb. Ex dc compounds could be potent inhibits for snake venom metalloproteinase (SVMP) a molecular docking and simulation studies. Asian Journal of Research in Biological and Pharmaceutical Sciences. 5(2), 2017, 50- 74.
59. Gurpreet K Grewal, Khuraijam D Singh, Neha Kanojia, Chitra Rawat, Samiksha Kukal, Ajay Jajodia, Anshika Singhal, Richa Misra, Selvaraman Nagamani, Karthikeyan Muthusamy, Ritushree Kukreti. Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach. Journal of Pharmaceutical research. PMID: 28432535, DOI: 10.1007/s11095-017-2161-z (IF: 3.002)
58. Arunachalam Kalaiarasi, Chidambaram Anusha,, Renu Sankar, Subbiah Rajasekaran, Jayaraj John Marshal, Karthikeyan Muthusamy, and Vilwanathan Ravikumar. Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin  Remodeling by Modulation of Histone Deacetylase To Induce  Growth Arrest and Apoptosis in the A549 Cell Line. Journal of Agricultural and Food Chemistry (ACS Publications). (IF: 2.8) 2016. PMID: 27936791, DOI:10.1021/acs.jafc.6b04453.
57. Biswajit G, Karthikeyan M, Sivaraman T*. Putative membrane lytic sites of P-type and S-type cardiotoxins as probed by molecular dynamic simulations. Journal of Molecular Modeling, 2016 (Accepted). (IF (2016) : 1.43).
56. Karthikeyan M*, Sathishkumar C, Nagarajan S, Sivaraman T. Ikshusterol3-O-glucoside of Clematis gouriana Roxb. ex DC. Inhibit the Plospholiase A2 of Snake venom: A in silico and in vitro study. Journal of Receptors and Signal Transduction (Accepted), 2016 Sep. (IF (2015): 1.782).
55. Vijayashree Priyadharsini, M.Karthikeyan, V.Shridevi, A. Paramasivam, G.Jayaraman, S.T.Santhiya. Association of CDH13 (rs7200009) gene polymorphism with essential hypertension in south Indian population. International Journal of Current research. 2016.
54. Sathishkumar C, Nagarajan S, Sivaraman T, Selvakumar C and Karthikeyan M*. Isolation and Characterization of Bioactive Compounds of Clematis gouriana Roxb. ex DC Against Snake Venom Phospholipase A2 (PLA2)  Computational and In vitro Insights. Journal of Biomolecular Structure and Dynamics, 2016. DOI:10.1080/07391102.2016.1202862 (IF (2015): 2.3).
53. Chinnasamy Selvakkumar*, Karthikeyan Muthusamy  and Sathish Kumar Chinnasamy. Nanopeptides: Non - Covalent Interactions in Chemistry and Biological Functions. J App Pharm 2016, 8:2; 1-8. (Doi.org/10.4172/1920-4159.1000218).
52. Karthikeyan M*, Prasad S, Nagamani S. Role of Hydrophobic Patch in LRP6: A Promising Drug Target for Alzheimer's disease, Indian Journal of Pharmaceutical Sciences, 2016; 78(2):240-251. (IF (2015): 0.762).
51. Karthikeyan M*, Mohan S, Nagamani S, Chandrasekhar K*. Identification of novel small molecules that bind to the loop 2 region of Sclerostin- an In silico computational Analysis, Physiological Research, (Accepted) (IF (2015): 1.293).
50. Selvakumar C, Karthikeyan M, Sathiskumar C*. Introduction of Stereo chemical onstraints in to Beta-Amino Acid residues, Journal of Vaccines and Immunology, 2016:2(1):001-003. (mini review).
49. Nagamani S, Singh KD, Karthikeyan M*. Combined sequence and sequence-structure based methods for analyzing FGF23, CYP24A1 and VDR genes. Meta Gene, 2016; 9:26-36. Elsevier publication.
48. Nagamani S, Saravana Kumar S, Karthikeyan M*. The binding mode prediction and similar ligand potency in the active site of vitamin D receptor (VDR) with QM/MM interaction, MESP and MD simulation, Chemical Biology & Drug Design, 2016 Feb 29, DOI:10.1111/cbdd.12754 (IF(2015): 2.802).
47. Gopinath K, David Raj C, Nagarajan S, Karthikeyan M*. Antidiabetic, Antihyperlipidemic and Antioxidant activity of Syzygium densiflorum fruits in Streptozotocin and Nicotinamide induced diabetic rats, Pharmaceutical Biology, 2015 Dec 24, DOI: 10.3109/13880209.2015.1125932 (IF (2014): 1.241)
46. Karthikeyan M*, Gopinath K . A computational study on role of 6-(hydroxymethyl)-3-[3,4,5-trihydroxy-6-[(3,4,5-trihydroxyoxan-2-yl)oxymethyl]oxan-2-yl]oxyoxane-2,4,5-triol in the regulation of blood glucose level. Journal of Biomolecular Structure and Dynamics, 2015 Nov 26. DOI:10.1080/07391102.2015.1124289   (IF (2014): 2.919)
45. Nagamani S, John Marshal J, Karthikeyan M*. E-Pharmacophore filtering and molecular dynamics simulation studies in the discovery of potent drug-like molecules for Chronic Kidney Disease. Journal of Biomolecular Structure and Dynamics, 2015 Oct 29. DOI:10.1080/07391102.2015.1111168 (IF (2014): 2.919)
44. Sathishkumar C, Selvakkumar C, Karthikeyan M*. High affinity selective inhibitor against phospholipase A2 (PLA2): A computational study. Journal of Receptors and Signal Transduction, 2015 Sep 30. DOI:10.3109/10799893.2015.1056306 (IF (2014): 2.277).
43. Gopinath K, Karthikeyan M*. Understanding the evolutionary relationship of M2 channel protein of influenza A virus and its structural variation and drug resistance. Current Bioinformatics, 2015 (Accepted) (IF (2014): 0.921)
42. Karthikeyan M*, Gopinath K, Nandhini D. Computational prediction of immunodominant antigenic region and potential protective epitopes for dengue vaccination. Indian Journal of Medical Research, 2015 Sep 01 (Accepted) (IF (2014): 1.396)
41. Gopinath K, Karthikeyan M*. In vitro evaluation of antioxidant and antidiabetic activities of Syzygium densiflorum fruits. Asian Pacific Journal of Tropical Disease, 2015 Nov 12; 5; 912-917. (Elsevier publication)
40. Sathishkumar C, Nagamani S, Karthikeyan M*. Zn2+ ion of the snake venom metalloproteinase (SVMP) plays a critical role in the ligand binding: A molecular dynamics simulation study. RSC Advances, 2015 Aug 18; 5; 70566-70576 (IF (2014): 3.84)
39. Sathishkumar C, Selvakkumar C, Nagamani S, Karthikeyan M*. Identification of potent inhibitors against snake venom metalloproteinase (SVMP) using molecular docking and molecular dynamics studies. Journal of Biomolecular Structure & Dynamics, 2015 Jul 01; 33(7): 1516-1527.  (IF (2014): 2.919)
38. Ajay J, Singh KhD, Anshika S, Saurabh V, Malabika D, Yogendra S, Karthikeyan M, Kukreti R. Methylation of HTR3A promoter variant alters binding of transcription factor CTCF. RSC Advances, 2015 May 21; 5 (57) : 45710-45717 (IF (2014): 3.84)
37. Gopinath K, Jayakumararaj R, Karthikeyan M*. DAPD: A knowledgebase for Diabetes Associated Proteins. IEEE Transactions on Computational Biology and Bioinformatics, 2015 May 1; 12 (3): 604 – 610. (IF (2013): 1.438)
36. Karthikeyan M*, Kirubakaran P, Gopinath K, Raja Rajeshwari T. Computational insights into the inhibition of H1N1, H3N3 and Influenza B viruses by Rupestonic acid derivatives: Pharmacophore modeling, 3D-QSAR, CoMFA and COMSIA studies. Combinatorial Chemistry & High Throughput Screening, 2015 Jan 01; 18(1): 63-74. (IF (2013): 1.222)
35. Nagamani S, Shanmuga Perumal M, Leela Shanmuga Perumal R, Kesavan C, Karthikeyan M*. ACE DD genotype associated with the female Chronic Kidney Disease patients of Tamilnadu population. The Egyptian Journal of Medical Human Genetics, 2015 Jan 01, 16 (1): 29-33. (Elsevier publication)
34. Singh KhD, Kirubakaran P, Nagamani S, Karthikeyan M*. Binding mode analysis of anti-influenza drugs in H1N1 (2009) and H5N1 influenza A virus and designing of potential H1N1. International Journal of Computational Biology and Drug Design, 2015 Jan 01, 8 (1); 1-18.
34. Singh KhD, Ajay J, Kaur H, Kukreti R, Karthikeyan M*. Renin Angiotensin System gene polymorphisms in response to antihypertensive drugs and visit-to-visit blood pressure variability in essential hypertensive patients. Current Pharmacogenomics and Personalized Medicine, 2014 12 (1), 227-235 (Bentham Science Publishers)
33. Singh KhD, Karthikeyan M*. Combined sequence and sequence-structure-based methods for analyzing RAAS gene SNPs: a computational approach. Journal of Receptors and Signal Transduction Research, 2014 Dec 01; 34 (6):  513-526. (IF (2013):1.611)
32. Kirubakaran P, Arunkumar P, Premkumar K, Karthikeyan M*. Sighting of Tankyrase inhibitors by structure and ligand based screening and in vitro approach. Molecular BioSystems (RSC), 2014 July 14; 10, 2699-2712.  (IF(2013): 3.35)
31. Singh KhD, Karthikeyan M*.Combined sequence and sequence-structure-based methods for analyzing RAAS gene SNPs: a computational approach. Journal of Receptors and Signal Transduction Research2014 May 30; 1-14. (IF (2013):1.611)
30. Karthikeyan M*, Kirubakaran P, Singh KhD, Bhuvaneshwari S, Gopinath K. Understanding the evolutionary relationship of HA protein from influenza viruses using phylogenetic approach and molecular modeling studies. Journal of Biomolecular Structure & Dynamics, 2014 May 01; 32 (5). 816-830. (IF (2013): 2.983)
29. Singh KhD, Naveena Q, Karthikeyan M*. Jak2 inhibitor – a jackpot for pharmaceutical industries: a comprehensive computational method in the discovery of new potent Jak2 inhibitors. Molecular BioSystems (RSC), 2014 Apr 14; 10. 2146-2159. (IF(2013): 3.35)
28. Singh KhD, Ajay J, Harpreet K, Ritushree K, Karthikeyan M*. Gender specific association of RAS gene polymorphism with essential hypertension – a case control study.  BioMed Research International, 2014 Apr 17; (DOI: 10.1155/2014/538053). (IF (2013): 2.706)
27. Kirubakaran P, Kothandan G, Cho SJ, Karthikeyan M*. Molecular insights on TNKS1/TNKS2 and inhibitor-IWR1 interactions. Molecular BioSystems (RSC), 2014 Jan 01. 10, 281-293. (IF(2013): 3.35)
26. Karthikeyan M*, Shridevi V, Rajiv Rose, Anandan B, Singh KhD, Shanmugasundaram S,  Mohan D, Ramesh, Jayaraman G. Angiotensin Gene Polymorphisms (T174M and M235T) are Significantly Associated with the Hypertensive Patients of Tamil Nadu, South India. International Journal of Human Genetics, 2013 Dec 1; 13(4): 201-207. (IF (2012): 0.19)
25. Singh KhD, Karthikeyan M*. Molecular Modeling, Quantum Polarized Ligand Docking and Structure Based 3D-QSAR study of imidazole series as Dual Endothelin and Angiotensin II Receptor Antagonists. Acta Pharmacologica Sinica (NPG), 2013 Dec 1; 34, 1592-1606. (IF (2012): 2.496)
24. Kirubakaran P, Karthikeyan M*. Pharmacophore modeling, 3D-QSAR and DFT studies of IWR small-molecule inhibitors of Wnt response. Journal of Receptors and Signal Transduction, 2013 Oct 1; 33 (5) 276-285. (IF (2012): 1.63)
23. Kirubakaran P, Karthikeyan M*, Singh KhD, Nagamani S. Pharmacophore modeling, 3D-QSAR and molecular docking study on naphthyridine derivatives as inhibitors of 3-phosphoinositide-dependent protein kinase-1. Medicinal Chemistry Research, 2013 Aug 01; 22 (8): 3812-3822.  (IF (2012) : 1.61)
22. Karthikeyan M*, Dhanachandra Singh Kh, Sathishkumar C, Nagamani S, Gopinath K, Thiyagarajan C, Premkumar P, Anusuyadevi M. High Throughput Screening and E-pharmacophore filtering in the discovery of new BACE-1 inhibitors. Interdisciplinary Sciences: Computational Life Sciences, 2013 Jun 01; 5(2): 119-126.
21. Devi Kasinathan, , Nisha RG, Prabhu NM, Manikandan R, Karthikeyan M. Awareness on Type II Diabetes and Its Complication among Sivaganga District Population in Tamilnadu: A Cross Section Survey. Journal of Advanced Scientific Research, 2013 Feb 1. 4(1): 38-42.
20. Kirubakaran P, Karthikeyan M*, Singh KhD, Nagamani S, Premkumar K. In silico structural and functional characterization of the human TOPK by protein structure modeling and molecular dynamics studies, Journal of Molecular Modeling, 2013 Jan; 19(1):407-19. (IF (2012) : 1.98)
19. Nagamani S, Karthikeyan M*, Kirubakaran P, Dhanachandra Singh Kh,   Gopinath K.  Theoretical studies on benzimidazole derivatives as E. coli biotin carboxylase inhibitors. Medicinal Chemistry Research, 2012 Sep 01; 21 (9): 2169-2180.  (IF (2011) : 1.271)
18. Nagamani S, Kesavan C, Muthusamy K*. E-Pharmacophore mapping and docking studies on Vitamin D receptor (VDR), Bioinformation,  2012 Aug 02; 8(15):705-10. (IF (2011) : 1.0)
17. Kirubakaran P, Karthikeyan M*, Dhanachandra Singh Kh, Nagamani S.  Homology modeling, molecular docking and molecular dynamics study on Trichomonas vaginalis carbamate kinase. Medicinal Chemistry Research, 2012 Aug 01; 21(8): 2105-2016. (IF (2011) : 1.271)
16. Dhanachandra Singh Kh, Karthikeyan M*, Kirubakaran P, Sathya V,  Nagamani S. Structure-base drug discovery of ApoE4 inhibitor from the plant compound. Medicinal Chemistry Research, 2012 Jun 01; 21 (6): 825-833. (IF (2011) : 1.271)
15. Kirubakaran P, Muthusamy K*, Dhanachandra Singh Kh, Nagamani S. Ligand based pharmacophore modeling; Atom based 3D-QSAR analysis and Molecular docking studies of Phosphoinositide-dependent kinase-1 inhibitors. Indian Journal of Pharmaceutical Sciences, 2012 Mar; 74(2):141-51. (IF (2011) : 0.626)
14. Dhanachandra Singh Kh, Kirubakaran P, Manikandaprabhu S, Nagamani S, Srinivasan P, Karthikeyan M*. Docking studies of adenosine analogues with NS5 methyltransferase of Yellow Fever Virus. Indian Journal of Microbiology, 2012 Mar; 52(1): 28-34. (IF (2011) : 0.46)
13. Dhanachandra Singh Kh, Kirubakaran P, Nagarajan S, Sakkiah S, Muthusamy K, Velmurgan D, Jeyakanthan J.  Homology Modeling, Molecular Dynamics, e-Pharmacophore mapping and Docking Study of Chikungunya Virus nsP2 Protease.  Journal of molecular modeling, 2012 Jan; 18(1):39-51.  (IF (2011) : 1.871)
12. Rose R, Balakrishnan A, Muthusamy K, Arumugam P, Shanmugam S, Gopalswamy J. Myocilin mutations among POAG patients from two populations of Tamil Nadu, South India, a comparative analysis. Molecular Vision, 2011 Dec; 17:3243-53. (IF (2010) : 2.51)
11. Srinivasan P, Kumar SP, Karthikeyan M, Jeyakanthan J, Jasrai YT, Pandya HA, Rawal RM, Patel SK. Epitope-based immunoinformatics and molecular docking studies of Nucleocapsid protein (NP) and Ovarian Tumor (OTU) domain of Crimean-Congo haemorrhagic fever virus (CCHFV). Frontiers in Genetics, 2011 Nov 2; 2(72): 1-9.
10. Dhanachandra Singh Kh, Karthikeyan M*, Kirubakaran P, Nagamani S. Pharmacophore filtering and 3D-QSAR in the discovery of new JAK2 inhibitors. Journal of Molecular Graphics and Modelling, 2011 Sep; 30:186-97. (IF (2010) : 2.033)
09. Kirubakaran P, Roopa K, Dhanachandra Singh Kh, Nagamani S, Arjunan S, Karthikeyan M*.  In silico studies on marine actinomycetes as potential inhibitors for Glioblastoma multiforme. Bioinformation, 2011 Apr 22; 6(3): 100-106.
08. Karthikeyan M*, Kirubakaran P, Dhanachandra Singh Kh, Nagamani S, Sindhu S. Molecualr Docking studies of Bitter melon compounds against BRCA1 Protein. Journal of Pharmacy Research, 2011 Feb; 4 (2): 388-390.
07. Ramya S,  Gopinath K, Karthikeyan M, Sundarpandian SM, Periyathambi N, Sundarajan G, Jayakumararaj R. Effect of Crude Methanol Leaf Extracts of Andrographis paniculata (Burmf) Nees on Larvae of Helicoverpa armigera (Hübner). Environment & We an International Journal of Science & Technology, 2011 Jan; 6; 19-26.
06. Srinivasan P, Sudha A, Shahul Hameed A, Prasanth Kumar S, Karhtikeyan M. Screening of medicinal plant compounds against NS5B polymerase of hepatitis C virus (HCV) using molecular docking studies. Journal of Pharmacy Research, 2011 Jan; 4(1): 136-14.
05. Dhanachandra Singh Kh, Muthusamy K*. In silico genome analysis and drug efficacy test of   influenza A virus (H1N1) 2009. Indian Journal of Microbiology, 2009 Dec; 49(4): 358-64. (IF (2010) : 0.938)
04. Karthikeyan M, Rose R, Shridevi V, Anandan B, Shanmugasundaram S, Mohan D,  Ramesh A, Jayaraman G. Core Promoter Variants (A-20C, T-18C and G-6A) of the Angiotensinogen (AGT) Gene are not Significantly Associated with Hypertension in Patients of Tamilnadu, India. International Journal of Human Genetics, 2009 Mar; 9(1):  13-19.
03. Popish JS, Levein MG, Muthusamy K, Ehret M, Rathinavelu A. Assessment of ethnicity on Butyrylcholinesterase variant in Alzheimer’s patients and normal volunteers. Journal of Pharmacy Practice, 2008 Feb; 21(1): page no.58-60.
02. Narasimhan M, Rose R, Karthikeyan M, Rathinavelu A. Detection of HDM2 and VEGF co- expression in cancer cell lines: novel effect of HDM2 antisense treatment on VEGF expression.  Life Sciences, 2007 Oct 13; 81(17-18):1362-72. (IF (2006) : 2.583)
01. Rose R, Karthikeyan M, Anandan B, Jayaraman G. (2007). Myocilin mutation among primary open angle glaucoma patients of kanyakumari district, South India.  Molecular Vision, 2007 Apr 2; 13:497-503.  (IF (2006): 2.38)